High glucose and diabetes enhanced store-operated Ca entry and increased expression of its signaling proteins in mesangial cells
نویسندگان
چکیده
Sarika Chaudhari, Peiwen Wu, Yanxia Wang, Yanfeng Ding, Joseph Yuan, Malcolm Begg, and Rong Ma Department of Integrative Physiology and Cardiovascular Research Institute, University of North Texas Health Science Center, Fort Worth, Texas; Department of Endocrinology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, People’s Republic of China; and Respiratory Therapy Area Unit, Medicine Research Center, GlaxoSmithKline, Stevenage, United Kingdom
منابع مشابه
High glucose and diabetes enhanced store-operated Ca(2+) entry and increased expression of its signaling proteins in mesangial cells.
The present study was conducted to determine whether and how store-operated Ca(2+) entry (SOCE) in glomerular mesangial cells (MCs) was altered by high glucose (HG) and diabetes. Human MCs were treated with either normal glucose or HG for different time periods. Cyclopiazonic acid-induced SOCE was significantly greater in the MCs with 7-day HG treatment and the response was completely abolished...
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تاریخ انتشار 2014